Funding search · Down syndrome · California
Who funds Down syndrome work in California
15 funders have a record of paying for Down syndrome work by California recipients: 76 grants totaling $4.1M, most recently in 2025 — mostly private foundations, plus grantmaking charities. The largest by matched giving are Pitt Hopkins Research Foundation ($375,614), Quest Foundation ($398,000) and International Rett Syndrome Foundation ($412,500).
From IRS Form 990-PF and 990 Schedule I filings, 2019–2025. Grants already paid to California recipients — evidence of what these funders back, not open calls.
Pitt Hopkins Research FoundationWinstonsalem, NCCharity · may take applications
6 matching grants · $375,614 · through 2025Largest: $125,000 to UNIVERSITY OF CALIFORNIA - SAN DIEGO — to support research projects on pitt hopkins syndrome
Largest: $40,000 to THE NEPHROTIC SYNDROME FOUNDATION (CO SOCIAL GOOD FUND) — backpacks of hope - the nephrotic syndrome foundation
International Rett Syndrome FoundationCincinnati, OHCharity · may take applications
5 matching grants · $412,500 · through 2024Largest: $150,000 to The Regents of the University of California US San Diego — rett syndrome research
Foundation for Angelman SyndromeAustin, TXCharity · may take applications
6 matching grants · $1.0M · through 2024Largest: $274,044 to REGENTS OF THE UNIVERSITY OF CALIFORNIA DAVIS — ft2022-007: gastrointestinal biomarkers in preclinical models of angelman syndrome
Largest: $50,000 to DOWN SYNDROME CONNECTION OF THE BAY AREA — first of three annual payments towards general operating budget
Largest: $10,000 to DOWN SYNDROME ASSOCIATION OF ORANGE COUNTY — general operating support
Noll FoundationWalnut Creek, CA
4 matching grants · $160,000 · through 2025Largest: $45,000 to DOWN SYNDROME CONNECTION — assistance to children with down's syndrome
Largest: $25,000 to DOWN SYNDROME FOUNDATION OF ORANGE COUNTY — to further the charitable purpose
Largest: $15,682 to FDN FOR PRADER-WILLI RESEARCH — support prader-willi syndrome research
Rite Aid Healthy FuturesEtters, PACharity · may take applications
6 matching grants · $61,013 · through 2024Largest: $10,263 to DOWN SYNDROME ASSOCIATION OF LOS ANGELES INC — support local kids programs
Largest: $33,400 to DOWN SYNDROME ASSN OF CENTRAL CALIFORNIA — assistance for children and their families with down syndrome
Alzheimer'S Disease Research FoundationWellesley Hills, MACharity · may take applications
3 matching grants · $862,492 · through 2025Largest: $402,492 to UNIVERSITY OF CALIFORNIA IRVINE — proteomic signatures of cerebrovascular neuropathology in down syndrome with alzheimer disease
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Start with one paperBroader: Down syndrome funders nationally · all California-based grantmakers