Funding search · EIN 137184401 · New York, NY

The Leona M and Harry B Helmsley

Name: The Leona M and Harry B Helmsley grants, 2021–2024
Creator: PaperOrbit
License: https://www.irs.gov/charities-non-profits/exempt-organization-public-disclosure-and-availability-requirements

A private foundation (files IRS Form 990-PF). Most private foundations do not take unsolicited applications; the route in is usually a program officer.

2,251
grants reported: $1.69B
total given: 2021–2024
filing years: $393,039
median grant

Based on grants this organization reported to the IRS for tax years 2021–2024. This is what they filed, not a complete record of their giving, and recent years may be incomplete because filings lag.

What they fund

disease crohns health diabetes center type ultrasound care

Funder website ↗Full IRS filings ↗How this is built Report an error

Funding pattern

What this funder pays for, at what size, and how to position adjacent work. Read from their filings, with every number checked against the record.

Where the money goes

Type 1 diabetes care, prevention trials, and global access
Crohn's disease mechanism, diagnostics, and therapeutic research
Rural US hospital equipment and capital, especially Upper Midwest and Hawaii
Israeli hospital construction and university science buildings
Sub-Saharan Africa health systems, WASH, and maternal-child care
Emergency and telehealth systems: stroke, ECMO, point-of-care ultrasound

Typical grant

Median grant is about $393,000, with the middle half between $156,000 and $927,000. The seven-figure checks go to two things: bricks and equipment (hospital wings in Israel, cancer centers in Hawaii, ultrasound fleets across North Dakota and Minnesota) and multi-year research or scale-up commitments in T1D and Crohn's, often $1.5M to $5M. Repeat giving is the norm, and the same recipient frequently appears two or three times in one year as a multi-payment award.

Their words

Phrases from their own grant descriptions, worth speaking back to them.

“T1D”
“Crohn's disease”
“ultrasound initiative”
“scaling”
“quality improvement”
“access to primary care”

Positioning adjacent work

Frame diabetes work as T1D specifically, tied to outcomes, registries, or quality improvement collaboratives.
For Crohn's, propose mechanistic or precision-diagnostic science with a defined trial or dataset endpoint.
Rural health proposals should name equipment, training, and geography: Dakotas, Minnesota, Montana, Hawaii.
Ask $1.5M to $3M multi-year for research; capital requests run $2M to $5M.

Worth knowing: Giving is concentrated in a small set of long-term partners (T1D Exchange, Blue Circle Health, Helmholtz Zentrum Munchen, Clalit, Billings Clinic, American Heart Association) and reads as relationship-driven and invited rather than competitive. Beyond the coastal research hubs in NY, MA, and CA, the money follows named geographies: rural Upper Midwest, Hawaii, Israel, and Ghana-centered Africa work.

26 grants matching “immunotherapies” · $13.8M

$1.3M
Washington University · Saint Louis, MO · 2024
Preclinical development to advance a t1d antigen-specific immunotherapy called saga-t1d
$152,801
University of Birmingham · 2024
Defining the efficacy and mechanisms of peptide immunotherapy for type 1 diabetes an experimental medicine study
$137,417
The Governors of the University of Calgary · 2024
Interleukin-4 activated macrophages (m(il4)) for personalized cellular immunotherapy to treat ibd
$127,077
The Governors of the University of Calgary · 2024
Interleukin-4 activated macrophages (m(il4)) for personalized cellular immunotherapy to treat ibd
$1.3M
The University of Queensland · 2023
Liposomal antigen-specific immunotherapy of recent-onset type 1 diabetes
$809,757
Benaroya Research Institute at Virginia Mason · Seattle, WA · 2023
Linking disease mechanism and clinical trial design via rapidly conducted immunotherapy trials in t1d
$556,499
Albert Einstein College of Medicine · Bronx, NY · 2023
Preclinical activities to advance d-peptides as an antigen-specific immunotherapy for type 1 diabetes
$506,886
University of Birmingham · 2023
Creating an optimised antigen-specific immunotherapy for type 1 diabetes
$494,612
Albert Einstein College of Medicine · Bronx, NY · 2023
Preclinical activities to advance d-peptides as an antigen-specific immunotherapy for type 1 diabetes
$275,000
The University of Texas Southwestern Medical Center · Dallas, TX · 2023
Immune checkpoint engineered beta cell as an antigen-specific immunotherapy for the treatment of type i diabetes
$137,153
The Governors of the University of Calgary · 2023
Interleukin-4 activated macrophages (m(il4)) for personalized cellular immunotherapy to treat ibd
$131,733
Benaroya Research Institute at Virginia Mason · Seattle, WA · 2023
Linking disease mechanism and clinical trial design via rapidly conducted immunotherapy trials in t1d
$126,154
The Governors of the University of Calgary · 2023
Interleukin-4 activated macrophages (m(il4)) for personalized cellular immunotherapy to treat ibd
$80,506
University of Birmingham · 2023
Defining the efficacy and mechanisms of peptide immunotherapy for type 1 diabetes: an experimental medicine study
$1.7M
University of Kansas Center for Research · Lawrence, KS · 2022
Preclinical development to advance a type 1 diabetes antigen-specific immunotherapy called saga-t1d
$322,498
University of Birmingham · 2022
Defining the efficacy and mechanisms of peptide immunotherapy for type 1 diabetes: an experimental medicine study
$275,000
The University of Texas Southwestern Medical Center · Dallas, TX · 2022
Immune checkpoint engineered beta cell as an antigen-specific immunotherapy for the treatment of type i diabetes
$126,830
University of Zurich · 2022
Generate bispecific interleukin-2 immunotherapy to treat t1d mellitus
$122,854
The Governors of the University of Calgary · 2022
Interleukin-4 activated macrophages (m(il4)) for personalized cellular immunotherapy to treat ibd
$119,554
The Governors of the University of Calgary · 2022
Interleukin-4 activated macrophages (m(il4)) for personalized cellular immunotherapy to treat ibd
$2.4M
Albert Einstein College of Medicine · Bronx, NY · 2021
Preclinical work to advance d-peptides as antigen-specific immunotherapy
$1.2M
The University of Queensland · 2021
Liposomal antigen-specific immunotherapy of recent-onset t1d
$750,000
Parker Institute for Cancer Immunotherapy · San Francisco, CA · 2021
Studying autoimmune diabetes following certain cancer immunotherapies.
$413,518
University of Birmingham · 2021
Defining the efficacy and mechanisms of peptide immunotherapy for t1d.
$118,250
University of Zurich · 2021
Generate bispecific interleukin-2 immunotherapy to treat t1d mellitus
$102,647
University of Birmingham · 2021
Antigen specific immunotherapy in type 1 diabetes

Top recipients

Repeat recipients are the strongest signal of whether a funder has an open door or quietly re-funds the same organizations.

Helmholtz Zentrum Munchen (Gmbh)42 grants · $52.3M
Blue Circle Health11 grants · $45.4M
Shaare Zedek Medical Center22 grants · $42.6M
Clalit Health Services37 grants · $41.7M
American Heart Association20 grants · $30.7M
Regents of the University of Minnesota16 grants · $30.4M
The End Fund4 grants · $30.0M
The Regents of the University of Colorado Denver49 grants · $22.5M
Mass General Brigham for the Brigham and Women'S Hospital7 grants · $21.5M
Catholic Relief Services-Usccb13 grants · $21.4M

Giving over time

$382.7M

2021

$427.5M

2022

$440.0M

2023

$439.5M

2024

Grant history

The 100 largest of 2,251 grants.

$22.5M
The End Fund · New York, NY · 2022
Neglected tropical disease: reaching the last mile
$15.6M
Blue Circle Health · Wilmington, DE · 2021
Creation of blue circle health for underserved communities with t1d
$12.6M
Regents of the University of Minnesota · Minneapolis, MN · 2021
Minnesota first responder aed project
$9.9M
Shaare Zedek Medical Center · 2021
The helmsley cancer center at shaare zedek medical center jerusalem
$9.0M
Mass General Brigham for the Brigham and Women'S Hospital · Boston, MA · 2023
Pen-plus expansion
$7.0M
Engineering Ministries International USA · Colorado Springs, CO · 2022
Alaska wash project
$7.0M
American Heart Association · Dallas, TX · 2024
American heart association center for telehealth
$6.8M
Mass General Brigham for the Brigham and Women'S Hospital · Boston, MA · 2024
Accelerating progress and promoting quality t1d care for the poorest billion through the global pen-plus partnership
$6.7M
Engineering Ministries International USA · Colorado Springs, CO · 2021
Alaska wash project
$6.6M
Nevada Department of Health and Human Services · Carson City, NV · 2022
Nevada first responder aed project
$6.6M
Geoscience Australia · 2022
Digital earth africa - sustainable uptake and impact
$6.4M
Commonwealth Healthcare Corporation · 2023
Cnmi chcc mri/medical equipment upgrade project
$6.1M
Yitzhak Shamir Medical Center · 2022
Expansion and renovation of the cancer institute at shamir medical center
$5.8M
Ben-Gurion University of the Negev · 2024
Construction of the leona m. And harry b. Helmsley charitable trust computer science building
$5.7M
Brigham and Women'S Hospital · Boston, MA · 2022
Pen-plus expansion
$5.6M
Nebraska Department of Health & Human Services · Lincoln, NE · 2021
Nebraska first responder aed project
$5.4M
Tzafon Medical Center · 2023
The helmsley rehabilitation center of the north
$5.3M
Iowa Department of Public Health · Des Moines, IA · 2021
Iowa first responder aed initiative
$5.3M
Hadassah Medical Organization · 2024
Equipping the new hadassah - helmsley medical center, netivot
$5.3M
Bridges To Prosperity · Denver, CO · 2021
Transformative connectivity in rural ethiopia
$5.2M
Shaare Zedek Medical Center · 2022
The helmsley cancer center at shaare zedek medical center jerusalem
$5.2M
Shaare Zedek Medical Center · 2023
Linear accelerators for the radiotherapy institute
$5.1M
The Baruch Padeh Medical Center Poriya · 2021
The helmsley rehabilitation center of the north
$5.0M
Regents of the University of Minnesota · Minneapolis, MN · 2022
Redefining the future of emergency medicine
$5.0M
Billings Clinic Foundation · Billings, MT · 2024
Billings clinic surgical intensive care unit
$5.0M
Kapiolani Health Foundation · Honolulu, HI · 2024
Martha b. Smith cancer & infusion center at kapiolani medical center for women & children
$5.0M
Stichting the Ocean Cleanup · 2024
Develop and scale technologies to rid the oceans of plastics
$5.0M
The Queens Medical Center · Honolulu, HI · 2024
The queen's medical center - west oahu cancer center expansion
$5.0M
Shaare Zedek Medical Center · 2023
Development of the helmsley surgical wing
$5.0M
Stichting the Ocean Cleanup · 2023
Develop and scale technologies to rid the oceans of plastics
$5.0M
Civica Foundation · Lehi, UT · 2021
Affordable insulin biosimilars
$4.9M
St Rose Dominican Health Foundation · Henderson, NV · 2023
Dignity health - st. Rose dominican - siena campus ecmo program
$4.9M
Fairview Health Services · Minneapolis, MN · 2023
Improving survival outcomes through university of minnesota medical center ecmo center of excellence
$4.9M
Regents of the University of Minnesota · Minneapolis, MN · 2023
Minnesota first responder aed project
$4.9M
Tel Aviv Sourasky Medical Center - Ichilov Hospital · 2024
Construction of the sheltered -5 floor of the north tower
$4.5M
Baptist Medical Centre · 2024
Elevating maternal and pediatric healthcare
$4.5M
Blue Circle Health · Wilmington, DE · 2024
Development of blue circle health
$4.5M
Blue Circle Health · Wilmington, DE · 2024
Development of blue circle health
$4.5M
The Baruch Padeh Medical Center Poriya · 2022
The helmsley rehabilitation center of the north
$4.4M
World Health Organization · 2022
Strengthening the capacity of the global diabetes compact
$4.4M
The Sheba Fund for Health Services and Research (Ra) · 2023
The helmsley center for innovative surgical training
$4.2M
Altru Health System · Grand Forks, ND · 2024
Altru health system ultrasound initiative
$4.2M
American Heart Association · Dallas, TX · 2023
American heart association center for telehealth
$4.2M
Jerusalem College of Technology · 2022
Helmsley faculty of life and health sciences building
$4.1M
The End Fund · New York, NY · 2023
Reaching the last mile fund expansion
$4.1M
Zefat Academic College · 2021
Equipping zefat academic college's inst. For adv. Health training & ed.
$4.1M
Clalit Health Services · 2022
A new neonatal center for israels southern periphery at soroka medical center
$4.0M
Holy Rosary Healthcare Foundation · Miles City, MT · 2022
Holy rosary healthcare comprehensive cancer center
$4.0M
Blue Circle Health · Wilmington, DE · 2024
Development of blue circle health
$3.9M
Wilcox Health Foundation · Lihue, HI · 2024
Wilcox medical center equipment revitalization project
$3.9M
Clalit Health Services · 2021
Medical equipment for carmel medical center in haifa, israel
$3.9M
Hadassah Medical Organization · 2022
Creating and equipping a new comprehensive diagnostic and interventional imaging center
$3.8M
Clalit Health Services · 2022
Yoseftal hospital addition
$3.8M
St Alexius Medical Center · Bismarck, ND · 2024
Chi st. Alexius health ultrasound initiative
$3.7M
New York University School of Medicine · New York, NY · 2023
Tamale education and innovation center for health
$3.7M
Central Montana Medical Facilities · Lewistown, MT · 2023
Cancer center at central montana medical center
$3.7M
T1d Exchange · Boston, MA · 2021
Data approach to improve quality and outcomes for individuals with t1d
$3.7M
Bhsh System · Grand Rapids, MI · 2022
Study the feasibility of telerobotic heart attack and stroke interventions
$3.7M
Helmholtz Zentrum Munchen (Gmbh) · 2021
Identification of infants with high risk of t1d - primary prevention
$3.6M
The Sheba Fund for Health Services and Research (Ra) · 2022
The helmsley center for innovative surgical training
$3.5M
Hillel Yaffe Medical Center · 2024
Construction of pet-ct institute
$3.5M
Maccabi Healthcare Services · 2021
Da vinci 4xi system dual console surgical robot and sterilization equip.
$3.5M
State of Nevada Department of Division of State Parks · Carson City, NV · 2024
Valley of fire visitor center
$3.5M
State of Nevada Department of Division of State Parks · Carson City, NV · 2023
Ice age fossil state park trails and outdoor amenities
$3.5M
State of Nevada Department of Division of State Parks · Carson City, NV · 2023
Valley of fire visitor center
$3.5M
Blue Circle Health · Wilmington, DE · 2022
Development of blue circle health
$3.5M
The Broad Institute · Cambridge, MA · 2024
Novel therapeutic approaches for crohns disease
$3.5M
Blue Circle Health · Wilmington, DE · 2023
Development of blue circle health
$3.5M
Indiana University · Indianapolis, IN · 2021
Ampath model replication in ghana
$3.5M
Central Montana Medical Facilities · Lewistown, MT · 2022
Cancer center at central montana medical center
$3.3M
Bar Ilan University in Israel · 2024
The leona m. And harry b. Helmsley energy prototype lab at bar-ilan university
$3.3M
New Venture Fund · Washington, DC · 2021
Type 1 diabetes camps project (2022 - 2024)
$3.3M
St Luke Health Care Foundation · West Chicago, IL · 2024
Hope center for women and children
$3.2M
Bar Ilan University · 2023
The leona m. And harry b. Helmsley energy prototype lab at bar-ilan university
$3.2M
Fairview Health Services · Minneapolis, MN · 2024
Improving survival outcomes through university of minnesota medical center ecmo center of excellence
$3.2M
Hillel Yaffe Medical Center · 2024
Eye institute and ambulatory surgery center
$3.1M
National Park Foundation · Washington, DC · 2022
Little bighorn battlefield national monument visitor center
$3.1M
World Health Organization · 2024
Strengthening the capacity of the global diabetes compact
$3.1M
World Health Organization · 2024
Strengthening integrated prevention and control of chronic and severe ncds in the who african region, using t1d, scd, arf, and rhd as entry points
$3.1M
Renown Health Foundation · Reno, NV · 2022
Simulation and innovation center at renown health
$3.1M
Clinton Health Access Initiative · Boston, MA · 2023
Improving medical oxygen production and utilization
$3.0M
Brigham and Women'S Hospital · Boston, MA · 2021
Global partnership to achieve universal access for t1d and ncds
$3.0M
St Luke Health Care Foundation · West Chicago, IL · 2023
Hope center for women and children
$3.0M
Trinity Health · Minot, ND · 2024
Trinity health ultrasound initiative
$3.0M
The Weizmann Institute of Science · 2024
Early childhood development and community center at the weizmann institute of science
$3.0M
Tel-Aviv University · 2023
Helmsley medical simulation center
$3.0M
The Weizmann Institute of Science · 2023
Early childhood development and community center at the weizmann institute of science
$3.0M
Diabetes Nsw · 2022
Improvements in outcomes for young people with diabetes in less-resourced countries
$3.0M
The Jewish Agency for Israel · 2022
Flights for new immigrants from russia
$3.0M
Avera McKennan Hospital and University Health Center · Sioux Falls, SD · 2021
Avera behavioral health center expansion
$3.0M
Jdrf T1d Fund Llc · Boston, MA · 2021
Jdrf t1d fund phase iii
$3.0M
South Dakota Parks & Wildlife Foundation · Pierre, SD · 2021
Custer state park bison center
$3.0M
The Broad Institute · Cambridge, MA · 2021
Novel therapeutic approaches for crohns disease
$3.0M
Children'S Mercy Hospital · Kansas City, MO · 2022
Type 1 diabetes rapid learning lab
$3.0M
Kmr Advancement of Medical Centers Ltd · 2021
Establishment of the health discovery tower
$2.9M
Helmholtz Zentrum Munchen (Gmbh) · 2023
Continuation of the gppad-02-study: identification of infants with increased type 1 diabetes risk for enrollment into primary prevention trials
$2.9M
Mass General Brigham for the Brigham and Women'S Hospital · Boston, MA · 2024
Real-time post-op touchless, remote monitoring in crohns disease the sapphire trial
$2.9M
Sanford · Fargo, ND · 2022
Sanford health ultrasound project
$2.9M
World Health Organization · 2023
Strengthening integrated prevention and control of chronic and severe ncds in the who african region, using t1d, scd, arf, and rhd as entry points
$2.9M
Jerusalem College of Technology · 2021
Helmsley faculty of life and health sciences building

View all 2,251 grants →

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Source: IRS Form 990-PF, Part XV, as filed by the foundation. These are grants already paid — a record of what this funder backs, not an open call.