Funding search · substance use and addiction · Missouri
Who funds substance use and addiction work in Missouri
15 funders have a record of paying for substance use and addiction work by Missouri recipients: 27 grants totaling $8.3M, most recently in 2025 — mostly private foundations, plus grantmaking charities. The largest by matched giving are St Joseph Medical Center Foundation ($6.0M), American Society of Addiction Medicine ($253,537) and Shepard McCaskill Foundation ($605,000).
From IRS Form 990-PF and 990 Schedule I filings, 2019–2025. Grants already paid to Missouri recipients — evidence of what these funders back, not open calls.
St Joseph Medical Center FoundationSt Louis, MOCharity · may take applications
3 matching grants · $6.0M · through 2023Largest: $2.0M to REDISCOVER — payment in accordance with missouri a/g settlement to provide comprehensive programs and services for men, women and children whose lives have been affected by mental illness and/o…
American Society of Addiction MedicineRockville, MDCharity · may take applications
3 matching grants · $253,537 · through 2025Largest: $120,098 to THE CURATORS OF THE UNIVERSITY OF MISSOURI AT KANSAS CITY — support for substance abuse and mental health services opioid str
Largest: $330,000 to AMETHYST PLACE INC — long-term supportive housing program for women and children recovering from generational poverty, substance use, and trauma
Largest: $5,000 to 4522 CLUB — addiction treatment & recovery
Largest: $186,809 to ST LOUIS UNIVERSITY — to assess state strategies to leverage block grants from the substance abuse and mental health services administration to improve the quality of substance use disorder treatment.
Largest: $50,000 to INVESTIGATIVE REPORTERS & EDITORS — substance use - harm reduction
Largest: $2,500 to TRI-COUNTY MENTAL HEALTH SERVICES INC — provide prevention and recovery-oriented mental health and substance use services which are quality assured and person-centered, with increased attention to the whole person.
The Institute for IntergovernmentalTallahassee, FLCharity · may take applications
2 matching grants · $98,890 · through 2022Largest: $49,445 to LEWIS & CLARK COUNTY — opioid overdose prevention activities and care programs upon release from incarceration
Largest: $253,386 to Parents as Teachers National Center — home visiting support for families affected by substance use disorder program
Largest: $209,199 to BE GREAT TOGETHER INC — 82048 documenting experiences of pregnant people who use opioids and interface with the criminal legal system to address maternal health disparities
Ssm Health FoundationSt Louis, MOCharity · may take applications
1 matching grant · $255,000 · through 2023Largest: $255,000 to SSM HEALTH CARE CORPORATION — opioid safety funding
Jackson County Community Children'SKansas City, MOCharity · may take applications
1 matching grant · $101,841 · through 2023Largest: $101,841 to GUADALUPE CENTERS — bilingual substance use prevention
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Start with one paperBroader: substance use and addiction funders nationally · all Missouri-based grantmakers